In the midst of central London, a successful Indian restaurant called 'Gaylord' is run by a Londoner of Indian origin called Pinu (Vinay Pathak) . A simple soul at heart, Pinu has many complexes - a special one being that he is a virgin and has experienced no intimacy with a woman. To top that, his biggest fear is to be laughed at by people... an ever-repeating phenomenon with him. Pinu is quite an introvert and has no real friends...the closest he has ever gotten to a friendship is with his foster brother Rajat (Siddhartha Makkar), who is quite a contrast to his own personality. A casual air about him, he is the lead singer of a rock band. Rajat is very fond of Pinu, though is often a source of annoyance to him as he finds Pinu really funny.

One day, a young Indian fellow called Kamlesh comes to his restaurant and asks for a job as a stand-up comedian. Quite thrown off, Pinu initially refuses but finally lets him join as a cook, who also does a stand-up act in the evenings. On the same day, he hires a new cashier - Renu (Gul Panag), a young art student from India, who has a passion for caricatures. Life changes dramatically for Pinu as Gaylord begins to transform... Renu works on the look of the place makes cheerful caricatures for customers while Kamles is a fabulous cook with a great talent for making people laugh in his acts and soon the restaurant is more happening and the business is much better. But the greatest difference they bring to his life is friendship. There is a visible difference in pinu's personality now as he lets himself hang out a bit with them.

One fine day, Pinu is thrown in to a daze as he walks away from the restaurant ...he has discovered a totally new fear - he might be Gay!!

Pinu seeks refuge in Rajat's advice which is quite simply - screw a woman!

On a mission now, Pinu goes on a rampage seeking available women for a sexual rendezvous. However, it leads to him suffering another string of tragicomic situations, ending up feeling humiliated...and laughed at!

'Straight!!' is a funny tale about Pinu, who struggles with himself, his fears and his complexes, to 'come out' as straight and find himself a love story.